
Are hallucinations and/or delusions common in people with Parkinson’s disease?
- Yes. Around 50% of people with PD may experience hallucinations and/or delusions over the course of their disease

What are hallucinations and/or delusions?
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A hallucination means seeing, hearing, or experiencing things that aren't real
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A delusion means believing things that aren’t true

How do people describe hallucinations and delusions?
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Hallucinations may be described as:
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Seeing things that aren't real, such as people, either living or deceased, animals, or objects
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Hearing things that aren't real, such as hearing sounds, music, or voices
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Smelling things that aren't there, like unusual odors
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Feeling something that isn't there, like something touching or moving on the skin
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Tasting something that isn't there, like experiencing an unusual taste in the mouth
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Delusions may be described as:
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Paranoia, such as believing people are talking to you or trying to access your money
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False beliefs, such as fears of your loved ones stealing from you, or loved ones putting you in harm's way
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Jealousy, such as believing a significant other is having an affair
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Beliefs that insignificant remarks or statements refer to you (eg, walking into a room of people laughing and assuming they are laughing at you)
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What is Parkinson's disease psychosis?
- Hallucinations and/or delusions are the most common symptoms of psychosis associated with Parkinson’s disease

What causes hallucinations and delusions?
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Currently there is no clear understanding of the exact cause of Parkinson’s‑related hallucinations and delusions
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However, these symptoms are thought to be caused by the following:
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A side effect of dopamine therapy. Hallucinations and delusions may be a side effect of common Parkinson's disease medications (called dopaminergic therapies). These medications increase dopamine levels in the brain, helping improve motor symptoms in patients with Parkinson’s disease. However, increasing dopamine levels may also cause changes that lead to hallucinations and delusions
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The natural progression of Parkinson’s disease. Hallucinations and/or delusions may be caused by changes in the brain that occur naturally as Parkinson’s disease progresses—regardless of whether or not you take any medications to increase your dopamine levels
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When do hallucinations and/or delusions typically occur?
- Parkinson’s‑related hallucinations and/or delusions typically occur in the later stages of Parkinson’s‑related, 10 or more years after initial diagnosis

Should I be worried about hallucinations and/or delusions?
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It’s important to speak to a healthcare provider if you or your loved one think you may be experiencing hallucinations and/or delusions
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Parkinson’s-related hallucinations and/or delusions may get worse over time, and people who experience these symptoms may not have the ability to identify whether or not what they’re experiencing is real

How do I help my loved one who may be experiencing hallucinations and/or delusions?
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You may use the Symptom Discussion Guide to help describe what they are experiencing to a healthcare provider
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You may use the Treatment Discussion Guide to help you prepare for a conversation with your healthcare provider
About NUPLAZID

What is NUPLAZID?
- NUPLAZID is a prescription medicine used to treat hallucinations (such as seeing, hearing, or experiencing things that aren't real and delusions (such as believing things that are not true) associated with Parkinson’s disease psychosis

What is the most important information I should know about the safety profile of NUPLAZID?
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Medicines like NUPLAZID can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia)
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NUPLAZID is not approved for the treatment of patients with dementia who experience psychosis unless their hallucinations and delusions are related to Parkinson’s disease

How can NUPLAZID help me?
- NUPLAZID may help to reduce the frequency and/or the severity of hallucinations and delusions associated with Parkinson’s disease psychosis. Individual results may vary

What if I only experience hallucinations and/or delusions and not both symptoms?
- Speak to your doctor to learn if NUPLAZID is right for you. NUPLAZID may help to reduce the frequency and/or the severity of hallucinations and delusions associated with Parkinson’s disease psychosis. Individual results may vary

How effective is NUPLAZID?
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In the clinical trial, the majority of patients who took NUPLAZID experienced fewer and/or less severe hallucinations and delusions when compared to placebo. And some patients did not experience any hallucinations or delusions at 6 weeks. Not everyone will respond to NUPLAZID. Individual results may vary
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NUPLAZID may begin to reduce hallucinations and delusions as soon as 4 weeks, but it may take up to 6 weeks to feel the full effect. You should speak with your healthcare provider before you stop taking NUPLAZID

Will NUPLAZID affect my Parkinson’s‑related movement issues?
- In the clinical trial, NUPLAZID had no effect on motor symptoms compared with a placebo at 6 weeks

How does NUPLAZID work?
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It is unclear how NUPLAZID actually works
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NUPLAZID is thought to work by blocking certain receptors associated with hallucinations and delusions

When was NUPLAZID FDA-approved for hallucinations and/or delusions associated with Parkinson's disease psychosis?
- NUPLAZID was approved by the FDA in 2016

Who shouldn't take NUPLAZID?
- Do not take NUPLAZID if you have had an allergic reaction to any of the ingredients in NUPLAZID. Allergic reactions have included rash, hives, swelling of the tongue, mouth, lips, or face, throat tightness, and shortness of breath. Speak with your doctor to find out if NUPLAZID is right for you
Taking NUPLAZID

How do I take NUPLAZID?
- The recommended dose of NUPLAZID is one 34 mg capsule, once daily by mouth, with or without food, taken around the same time every day, or as prescribed by your healthcare provider

Can I take NUPLAZID with the carbidopa/levodopa medicines I’m taking for Parkinson’s disease?
- NUPLAZID can be taken without adjusting carbidopa/levodopa medications. Some medicines should not be taken with NUPLAZID. Tell your healthcare provider about all of the medicines you are taking
Learn more about Taking NUPLAZID.

How long does it take for NUPLAZID to start working?
- NUPLAZID may begin to reduce hallucinations and delusions as soon as 4 weeks, but it may take up to 6 weeks to feel the full effect. You should speak with your healthcare provider before you stop taking NUPLAZID

What medicines might interact with NUPLAZID?
- Tell your healthcare provider about all the medicines you take. Other medicines may affect how NUPLAZID works. Some medicines should not be taken with NUPLAZID. Your healthcare provider can tell you if it is safe to take NUPLAZID with your other medicines. Do not start or stop any medicines while taking NUPLAZID without talking to your healthcare provider first

What warnings should I know about NUPLAZID?
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QT Interval Prolongation: NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval. Tell your healthcare provider about all the medicines you take or have recently taken
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Do not take NUPLAZID if you have certain heart conditions that change your heart rhythm. It is important to talk to your healthcare provider about this possible side effect. Call your healthcare provider if you feel a change in your heartbeat

What are the possible side effects of NUPLAZID?
The common side effects of NUPLAZID include
- Swelling in the legs or arms
- Nausea
- Confusion
- Hallucination
- Constipation
- Changes to normal walking
These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider or pharmacist about this medicine.
Getting NUPLAZID

How do I get NUPLAZID?
- Acadia Connect® can coordinate with you and the pharmacy filling the prescription to help get the medicine delivered wherever is most convenient to you
Learn more about Acadia Connect.

How much does NUPLAZID cost?
- There are options available that may help you cover the cost of NUPLAZID. Visit Acadia Connect to learn more

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Medicines like NUPLAZID can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).
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NUPLAZID is not approved for the treatment of patients with dementia who experience psychosis unless their hallucinations and delusions are related to Parkinson’s disease.
Who should not take NUPLAZID?
- Do not take NUPLAZID if you have had an allergic reaction to any of the ingredients in NUPLAZID. Allergic reactions have included rash, hives, swelling of the tongue, mouth, lips, or face, throat tightness, and shortness of breath.
- Do not take NUPLAZID if you have certain heart conditions that change your heart rhythm. It is important to talk to your healthcare provider about this possible side effect. Call your healthcare provider if you feel a change in your heartbeat.
What other warnings should I know about NUPLAZID?
- QT Interval Prolongation: NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval. Tell your healthcare provider about all the medicines you take or have recently taken.
Please also see What is the most important information I should know about NUPLAZID?
What medicine might interact with NUPLAZID?
- Tell your healthcare provider about all the medicines you take. Other medicines may affect how NUPLAZID works. Some medicines should not be taken with NUPLAZID. Your healthcare provider can tell you if it is safe to take NUPLAZID with your other medicines. Do not start or stop any medicines while taking NUPLAZID without talking to your healthcare provider first.
What are the common side effects of NUPLAZID?
- The common side effects of NUPLAZID include swelling in the legs or arms, nausea, confusion, hallucination, constipation, and changes to normal walking. These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider about this medicine.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088. You can also call Acadia Pharmaceuticals Inc. at 1‑844‑4ACADIA (1‑844‑422‑2342).
Indication
NUPLAZID is a prescription medicine used to treat hallucinations and delusions associated with Parkinson’s disease psychosis.
How should I take NUPLAZID?
The recommended dose of NUPLAZID is one 34 mg capsule once per day, taken by mouth, with or without food.
NUPLAZID is available as 34 mg capsules and 10 mg tablets.
Please read the full Prescribing Information, including Boxed WARNING.