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NUPLAZID is an FDA-approved treatment for hallucinations and delusions associated with Parkinson's disease psychosis.

Are Parkinson's disease–related hallucinations and delusions affecting you or your loved one?

Asking your healthcare provider about treatment could make all the difference.

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Parkinson’s disease–related hallucinations and delusions may be more common than you think

Around 50% of people living with Parkinson’s disease (PD) may experience hallucinations and/or delusions over the course of their disease.

If you or your loved one think you may be experiencing hallucinations or delusions, speak to your healthcare provider. Our doctor discussion guide may help you plan for the conversation.

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Watch Michael & Renee’s story

Seven years after being diagnosed with PD, Michael began to experience related hallucinations and delusions. In this video, his wife Renee shares their experiences and explains why reporting to your healthcare provider is so important.

These stories represent the experiences of actual patients and caregivers. The opinions expressed are their own, and individual experiences may vary. Always speak with your healthcare provider about your own experience.

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NUPLAZID: Real help for a real part of Parkinson’s disease psychosis

NUPLAZID is the only medicine FDA approved to reduce the frequency and/or severity of hallucinations and delusions associated with Parkinson's disease psychosis.

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Acadia Connect logo for patient, caregiver and healthcare professional support website

When starting a new medication, help can take many forms. The support you need one day may be completely different the next. It changes, just as you do. So the Acadia Connect promise is simple: be there.

We are here to help you or someone you love begin treatment with NUPLAZID. As a partner who understands what goes into starting a new medication, our support program is here to offer guidance and resources, every step of the way.

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Sign up. Stay informed.

Learn more about NUPLAZID and PD-related hallucinations and delusions.

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  • Medicines like NUPLAZID can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).

  • NUPLAZID is not approved for the treatment of patients with dementia-related psychosis unrelated to the hallucinations and delusions associated with Parkinson’s disease psychosis.

  • Do not take NUPLAZID if you have had an allergic reaction to any of the ingredients in NUPLAZID. Allergic reactions have included rash, hives, swelling of the tongue, mouth, lips, or face, throat tightness, and shortness of breath.
  • NUPLAZID may cause serious side effects including:

    • QT Interval Prolongation: NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval. Tell your healthcare provider about all the medicines you take or have recently taken.

    • Do not take NUPLAZID if you have certain heart conditions that change your heart rhythm. It is important to talk to your healthcare provider about this possible side effect. Call your healthcare provider if you feel a change in your heartbeat.

  • Tell your healthcare provider about all the medicines you take. Other medicines may affect how NUPLAZID works. Some medicines should not be taken with NUPLAZID. Your healthcare provider can tell you if it is safe to take NUPLAZID with your other medicines. Do not start or stop any medicines while taking NUPLAZID without talking to your healthcare provider first.
  • The common side effects of NUPLAZID include swelling in the legs or arms, nausea, confusion, hallucination, constipation, and changes to normal walking. These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider about this medicine.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.
You can also call Acadia Pharmaceuticals Inc. at 1‑844‑4ACADIA (1‑844‑422‑2342).


NUPLAZID is a prescription medicine used to treat hallucinations and delusions associated with Parkinson’s disease psychosis.

Dosage and Administration

The recommended dose of NUPLAZID is one 34 mg capsule once per day, taken by mouth.

NUPLAZID is available as 34 mg capsules and 10 mg tablets.

Please read the full Prescribing Information, including Boxed WARNING.