NUPLAZID is an FDA-approved treatment for hallucinations and delusions associated with Parkinson's disease psychosis.

NUPLAZID: Real help for a real part of Parkinson’s disease psychosis

Facts about NUPLAZID

Clinical trial results for NUPLAZID

NUPLAZID reduced the frequency and/or severity of Parkinson's disease
(PD)–related hallucinations and delusions

  • In the clinical trial, the majority of patients who took NUPLAZID experienced fewer and/or less severe hallucinations and delusions associated with PD psychosis

  • Some patients did not experience any hallucinations or delusions after 6 weeks. Not everyone will respond to NUPLAZID

The common side effects of NUPLAZID include swelling in the legs or arms, nausea, confusion, hallucination, constipation, and changes to normal walking. These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider about this medicine.

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NUPLAZID had no effect on motor symptoms

  • Taking NUPLAZID did not affect motor symptoms during the clinical trial compared to a placebo
Icon showing the palm of the hand represents motor symptoms of PD

Clinical trial details

  • To test the efficacy of NUPLAZID, an FDA-accepted tool measured the changes in the frequency and/or severity of hallucinations and delusions associated with PD psychosis

  • The clinical trial included 199 adults (at least 40 years of age with an average age of 72 years) diagnosed with hallucinations and delusions associated with PD psychosis that was severe and frequent enough for treatment

  • Each person was assigned to 1 of 2 groups: those who received NUPLAZID 34 mg or those who received placebo. Results were reported at the end of 6 weeks

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NUPLAZID works around-the-clock to help reduce hallucinations and delusions associated with PD psychosis

  • The recommended dose of NUPLAZID is one 34 mg capsule, once daily by mouth, with or without food, around the same time every day, or as prescribed by your healthcare provider

  • It’s important to remember that everyone responds to medications differently, so it may take some time for NUPLAZID to start working

Around-the-clock icon representing how NUPLAZID® works around-the-clock to help reduce PD-related hallucinations and delusions

Continuing to take NUPLAZID as prescribed may help you see results

  • NUPLAZID may begin to reduce hallucinations and delusions as soon as 4 weeks, but it may take up to 6 weeks to feel the full effect

  • You should speak with your healthcare provider before you stop taking NUPLAZID

Calendar icon represents PD-related hallucinations and delusions over time & how NUPLAZID® treats PD-related hallucinations and delusions over time
Taking NUPLAZID
  • You can take NUPLAZID without adjusting doses of carbidopa/levodopa medicines

  • NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval

  • Tell your healthcare provider about any changes in the medicines you are taking. Some prescriptions or over-the-counter medicines may interact with NUPLAZID and should not be taken

Important Safety Information

NUPLAZID may cause serious side effects including:

  • QT Interval Prolongation: NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval. Tell your healthcare provider about all the medicines you take or have recently taken.

  • Do not take NUPLAZID if you have certain heart conditions that change your heart rhythm. It is important to talk to your healthcare provider about this possible side effect. Call your healthcare provider if you feel a change in your heartbeat.

See below for additional Important Safety Information.

Icon of heartbeat rhythm line graph with red heart reflects potential serious side effects of NUPLAZID® that can change your heart rhythm
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Watch John's story

John is affected by hallucinations and delusions associated with Parkinson's disease psychosis. In this video, John speaks about the impact they have had on him, and his experience taking NUPLAZID to treat these symptoms.

These stories represent the experiences of actual patients. The opinions expressed are their own and individual experiences may vary. Always speak with your healthcare provider.

FAQs icon represents answers to FAQs about Parkinson’s disease–related hallucinations and delusions, and NUPLAZID® medication
Questions about treatment or your symptoms?
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Get more information about PD‑related hallucinations and delusions

IMPORTANT SAFETY INFORMATION and INDICATION

WARNING: INCREASED RISK OF DEATH IN ELDERLY PATIENTS WITH DEMENTIA–RELATED PSYCHOSIS

  • Medicines like NUPLAZID can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).

  • NUPLAZID is not approved for the treatment of patients with dementia-related psychosis unrelated to the hallucinations and delusions associated with Parkinson’s disease psychosis.

  • Do not take NUPLAZID if you have had an allergic reaction to any of the ingredients in NUPLAZID. Allergic reactions have included rash, hives, swelling of the tongue, mouth, lips, or face, throat tightness, and shortness of breath.
  • NUPLAZID may cause serious side effects including:

    • QT Interval Prolongation: NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval. Tell your healthcare provider about all the medicines you take or have recently taken.

    • Do not take NUPLAZID if you have certain heart conditions that change your heart rhythm. It is important to talk to your healthcare provider about this possible side effect. Call your healthcare provider if you feel a change in your heartbeat.

  • Tell your healthcare provider about all the medicines you take. Other medicines may affect how NUPLAZID works. Some medicines should not be taken with NUPLAZID. Your healthcare provider can tell you if it is safe to take NUPLAZID with your other medicines. Do not start or stop any medicines while taking NUPLAZID without talking to your healthcare provider first.
  • The common side effects of NUPLAZID include swelling in the legs or arms, nausea, confusion, hallucination, constipation, and changes to normal walking. These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider about this medicine.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.
You can also call Acadia Pharmaceuticals Inc. at 1‑844‑4ACADIA (1‑844‑422‑2342).

Indication

NUPLAZID is a prescription medicine used to treat hallucinations and delusions associated with Parkinson’s disease psychosis.

Dosage and Administration

The recommended dose of NUPLAZID is one 34 mg capsule once per day, taken by mouth.

NUPLAZID is available as 34 mg capsules and 10 mg tablets.

Please read the full Prescribing Information, including Boxed WARNING.