NUPLAZID questions and answers
Here you’ll find answers to some of the most frequently asked questions about NUPLAZID® (pimavanserin)—the first and only prescription medicine FDA-approved to treat hallucinations and delusions associated with Parkinson’s disease (PD) psychosis.
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- How effective is NUPLAZID?
NUPLAZID is proven to be effective in most people:
NUPLAZID works around the clock to help reduce Parkinson’s disease hallucinations and delusions
NUPLAZID works all day and night to help reduce hallucinations and delusions associated with Parkinson’s disease psychosis. You just take two 17‑mg tablets, once a day, at a time that you choose, or as prescribed by your doctor. It’s important to remember that everyone responds to medications differently, so it may take some time for NUPLAZID to start working.
Continuing to take NUPLAZID as prescribed may help you see results
NUPLAZID may begin to reduce hallucinations and delusions as soon as 2 weeks, but it may take up to 6 weeks to feel the full effect. You should speak with your doctor before you stop taking NUPLAZID.
NUPLAZID significantly reduced the number and/or severity of symptoms in the majority of people
In a clinical trial, the majority of people who took NUPLAZID experienced fewer and/or less severe symptoms. And, after 6 weeks, some people were no longer experiencing any symptoms.
To test the effectiveness of NUPLAZID, an FDA-accepted tool was used. The tool measures changes in the frequency or severity of hallucinations and delusions in people with Parkinson’s.Tell me more about the trial X
The clinical trial included 199 adults (at least 40 years of age with a mean age of 72 years) diagnosed with Parkinson’s disease psychosis that was severe enough for treatment. It was a randomized, double-blind, placebo-controlled study. Each person was assigned to 1 of 2 groups: those who received NUPLAZID or those who received placebo. Results were reported after 6 weeks.
- What might treatment with NUPLAZID mean for me?
If you experience hallucinations:
NUPLAZID may help to reduce the frequency and/or the severity of hallucinations.
If your delusions (or delusionary thoughts) occur frequently or seem real:
NUPLAZID can help you recognize that what you are experiencing is a symptom of Parkinson’s, and that it’s not “real.”
- Can I take NUPLAZID with other medicines I’m taking for Parkinson’s disease?
You can take NUPLAZID without adjusting doses of carbidopa/levodopa medicines. Some medicines should not be taken with NUPLAZID. Tell your doctor about all of the medicines you are taking.
- Will NUPLAZID affect my Parkinson’s-related movement issues?
NUPLAZID had no effect on motor symptoms during a clinical trial.
- How often do I take NUPLAZID?
With NUPLAZID, you simply take two 17‑mg tablets, once a day, at a time that you choose, or as prescribed by your doctor.
- What are the side effects of NUPLAZID?
The most common side effects of NUPLAZID include swelling in the legs or arms, nausea, and feeling confused. Other possible side effects are hallucinations, constipation, and changes to normal walking.
These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider about this medicine.
- How do I get NUPLAZID?
NUPLAZID is available only through specialty pharmacies.* Once your doctor prescribes NUPLAZID, he or she will also likely enroll you in NUPLAZIDconnect™—a program that helps you start the process of working with a specialty pharmacy, and guides you along the way. Click here to learn more about NUPLAZIDconnect.
* Specialty pharmacies operate much like the regular, retail pharmacies you’re used to, but they fill prescriptions for specialty medications, such as NUPLAZID. They also offer other services, such as delivery of the medication directly to your home.
“I’m scared to be alone. I never know when I’ll start to see things.”**Actor portrayal. Based on experiences shared by people living with Parkinson’s disease psychosis